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Image Search Results
Journal: bioRxiv
Article Title: Long-Read Structural and Epigenetic Profiling of a Kidney Tumor-matched Sample with Nanopore Sequencing and Optical Genome Mapping
doi: 10.1101/2024.03.31.587463
Figure Lengend Snippet: Experimental workflow. High molecular weight DNA was extracted from a ccRCC tumor and a normal adjacent tissue. Samples were analyzed by OGM and ONT to detect structural and copy number variations, and epigenetic modifications. Results from both methods were compared.
Article Snippet: Basecalling of raw POD5 files was performed using the
Techniques: High Molecular Weight
Journal: bioRxiv
Article Title: Long-Read Structural and Epigenetic Profiling of a Kidney Tumor-matched Sample with Nanopore Sequencing and Optical Genome Mapping
doi: 10.1101/2024.03.31.587463
Figure Lengend Snippet: Comparative analysis of structural variations (SVs) and copy number variations (CNVs) in a ccRCC tumor, as detected by ONT and OGM. A. CNV plots (log 2 of the copy ratio) generated from ONT (top) and OGM (bottom). Data illustrate highly similar findings, pinpointing a significant DNA loss on chromosome 3 and various losses and gains on chromosomes 5, 7 and 12. B. Venn diagrams displaying common and unique SVs to OGM and ONT, in four size ranges: 500 bp −1 kbp, 1-5 kbp, 5-10 kbp and above 10 kbp.
Article Snippet: Basecalling of raw POD5 files was performed using the
Techniques: Generated